Trending 7 years of in vitro activity of tigecycline and comparators against Gram-positive and Gram-negative pathogens from the Asia-Pacific region: Tigecycline Evaluation Surveillance Trial (TEST) 2004-2010

Stephen P Hawser; Samuel K Bouchillon; Meredith Hackel; Minjun Chen; Eui-Chong Kim

doi:10.1016/j.ijantimicag.2012.02.018

Trending 7 years of in vitro activity of tigecycline and comparators against Gram-positive and Gram-negative pathogens from the Asia-Pacific region: Tigecycline Evaluation Surveillance Trial (TEST) 2004-2010

Int J Antimicrob Agents. 2012 Jun;39(6):490-5. doi: 10.1016/j.ijantimicag.2012.02.018. Epub 2012 Apr 23.

Authors

Stephen P Hawser¹, Samuel K Bouchillon, Meredith Hackel, Minjun Chen, Eui-Chong Kim

Affiliation

¹ IHMA Europe Sàrl, 4 Route de Corniche, 1066 Epalinges, Switzerland. [email protected]

PMID: 22534507
DOI: 10.1016/j.ijantimicag.2012.02.018

Abstract

A total of 10948 clinical isolates was collected throughout the Asia-Pacific region as part of the Tigecycline Evaluation Surveillance Trial (TEST) during 2004-2010, consisting of 7549 Gram-negative and 3399 Gram-positive pathogens. Susceptibility trends for all species demonstrated several significant species-dependent susceptibility changes to multiple antibiotics. The most notable was minocycline, for which significant decreases in susceptibility (P<0.001) were observed for six of the ten species studied. In contrast, statistically significant susceptibility changes for tigecycline were observed in only two of the ten species, namely Klebsiella pneumoniae and Serratia marcescens. Seven years following the introduction of tigecycline into clinical use, this agent remains highly active against a wide range of pathogens from the Asia-Pacific region.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology*
Asia / epidemiology
Drug Resistance, Bacterial / drug effects*
Gram-Negative Bacteria / classification
Gram-Negative Bacteria / drug effects*
Gram-Negative Bacteria / isolation & purification
Gram-Negative Bacterial Infections / drug therapy
Gram-Negative Bacterial Infections / epidemiology
Gram-Negative Bacterial Infections / microbiology
Gram-Positive Bacteria / classification
Gram-Positive Bacteria / drug effects*
Gram-Positive Bacteria / isolation & purification
Gram-Positive Bacterial Infections / drug therapy
Gram-Positive Bacterial Infections / epidemiology
Gram-Positive Bacterial Infections / microbiology
Humans
Microbial Sensitivity Tests
Minocycline / analogs & derivatives*
Minocycline / pharmacology
Population Surveillance / methods*
Species Specificity
Tigecycline

Substances

Anti-Bacterial Agents
Tigecycline
Minocycline