Medical treatment of antral gastrin cell hyperfunction: role of nonantisecretory therapy

Digestion. 1990;46(2):65-71. doi: 10.1159/000200334.

Abstract

Antral G cell hyperfunction (AGCH) is a rare condition, often associated with severe duodenal ulcer disease poorly responsive to medical therapy. Up to now, no studies have been designed to investigate a possible role of medical treatment in the management of this syndrome. In this study we treated 9 AGCH patients with duodenal ulcer, unhealed with the prolonging standard doses of H2 antagonists (300 mg/day ranitidine or 800 mg/day cimetidine), with a nonantacid therapy, tripotassium dicitrato bismuthate (TDB). 6 out of 9 patients showed a complete healing after 8 weeks of treatment. The healing was irrespective to eradication of Campylobacter pylori. After 9 weeks' suspension of H2 blockers basal gastrin levels decreased significantly by 31.5%, whereas peak meal-stimulated levels, although decreased in 6 out 9 patients, were not significantly affected by the withdrawal of the H2 antagonists. Nonantisecretory therapy seems to be an efficacious alternative in the management of AGCH patients.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Anti-Ulcer Agents / therapeutic use*
  • Bismuth / therapeutic use*
  • Cimetidine / therapeutic use
  • Duodenal Ulcer / drug therapy*
  • Enterochromaffin Cells / metabolism
  • Female
  • Gastric Acid / metabolism
  • Gastrins / blood
  • Helicobacter Infections / drug therapy
  • Helicobacter pylori / isolation & purification
  • Humans
  • Male
  • Middle Aged
  • Organometallic Compounds / therapeutic use*
  • Ranitidine / therapeutic use

Substances

  • Anti-Ulcer Agents
  • Gastrins
  • Organometallic Compounds
  • Cimetidine
  • Ranitidine
  • bismuth tripotassium dicitrate
  • Bismuth