Abstract
Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alleles
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Animals
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Body Size / genetics*
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Body Size / physiology
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Genetic Association Studies / methods
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Genetic Loci
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Genetic Pleiotropy*
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Humans
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Linkage Disequilibrium
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Mammals / genetics*
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Mammals / physiology
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Mice
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Mice, Knockout
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Mutation
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Mutation Rate
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Pedigree
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Polymorphism, Genetic