Abstract
The safety of a new nootrope and neuroprotector--calcium N-(5-hydroxynicotinoyl)-L-glutamate (ampasse)--has been evaluated. It is shown that ampasse at a dose of 6.7 mg/kg (10 times the maximum therapeutic dose for humans) did not affect the reproductive function in experimental animals and did not produced any embryotoxic and teratogenic effects.
MeSH terms
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Animals
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Calcium / chemistry
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Estrous Cycle / drug effects
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Estrous Cycle / physiology
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Female
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Fertility / drug effects*
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Fertility / physiology
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Fetal Organ Maturity / drug effects
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Fetal Viability / drug effects
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Fetal Weight / drug effects
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Fetus
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Glutamates / chemical synthesis
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Glutamates / toxicity*
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Humans
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Injections, Intramuscular
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Litter Size / drug effects
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Male
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Neuroprotective Agents / chemical synthesis
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Neuroprotective Agents / toxicity*
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Nicotinic Acids / chemical synthesis
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Nicotinic Acids / toxicity*
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Nootropic Agents / chemical synthesis
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Nootropic Agents / toxicity*
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Parity / drug effects
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Parity / physiology
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Pregnancy
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Rats
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Reproduction / drug effects*
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Reproduction / physiology
Substances
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Glutamates
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Neuroprotective Agents
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Nicotinic Acids
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Nootropic Agents
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nooglutil
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Calcium