Holding on to stemness

Nat Cell Biol. 2012 May 2;14(5):450-2. doi: 10.1038/ncb2498.

Abstract

The attachment of stem cells to specialized functional niches instructs stem cell maintenance, with loss of adhesion associated with differentiation driven by cell-intrinsic programs. Id transcription factors are now shown to link cell-intrinsic maintenance programs and extrinsic cues by promoting adhesion of neural stem cells to the niche.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Neoplasm / physiology*
  • Cell Adhesion / physiology*
  • Neural Stem Cells / cytology*

Substances

  • Antigens, Neoplasm
  • Id tumor-specific protein, mouse