Biological effects of lysophosphatidic acid in the nervous system

Int Rev Cell Mol Biol. 2012:296:273-322. doi: 10.1016/B978-0-12-394307-1.00005-9.

Abstract

Lysophosphatidic acid (LPA) is a bioactive lipid that regulates a broad range of cellular effects in various cell types, leading to a variety of responses in tissues, including in the nervous system. LPA and its receptors are found in the nervous system, with different cellular and temporal profiles. Through its ability to target most cells of the nervous system and its induction of pleiotropic effects, LPA mediates events during neural development and adulthood. In this review, we summarize the current knowledge on the effects of LPA in the nervous system, during development and adulthood, and in various pathologies of the nervous system. We also explore potential LPA intervention strategies for anti-LPA therapeutics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Lysophospholipids / metabolism*
  • Nervous System / cytology
  • Nervous System / embryology*
  • Nervous System / growth & development
  • Nervous System / metabolism*
  • Receptors, Lysophosphatidic Acid / biosynthesis

Substances

  • Lysophospholipids
  • Receptors, Lysophosphatidic Acid
  • lysophosphatidic acid