Blood pressure in minimal change and other types of nephrotic syndrome

Am J Nephrol. 1990:10 Suppl 1:76-80. doi: 10.1159/000168198.

Abstract

Blood pressure was evaluated in adult patients (n = 9) and children (n = 57) with nephrotic syndrome and minimal change glomerulonephritis (GN). Prior to steroid treatment in the edematous phase, hypertension was found in 78% of adults (BP greater than or equal to 140/90 mm Hg or antihypertensive treatment other than diuretics) and 95% of children (BP greater than 95 percentile of age). After complete remission, the prevalence of hypertension decreased to 33% in adults and 19% in children. In 21 children with early focal segmental glomerulosclerosis, the prevalence of hypertension (BP greater than 95th percentile) was 91% and 24% after complete remission. In 20 adult patients with membranous GN, the prevalence of hypertension in the edematous phase was 89% and 30% after complete or partial remission. It is concluded that, irrespective of age, hypertension is a common feature of the nephrotic syndrome unrelated to steroid therapy or renal failure.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Antihypertensive Agents / therapeutic use
  • Blood Pressure / physiology*
  • Child
  • Female
  • Glomerulonephritis, Membranoproliferative / physiopathology
  • Glomerulosclerosis, Focal Segmental / physiopathology
  • Humans
  • Hypertension, Renal / drug therapy
  • Hypertension, Renal / epidemiology
  • Hypertension, Renal / etiology*
  • Male
  • Nephrosis, Lipoid / complications
  • Nephrosis, Lipoid / physiopathology*
  • Prevalence

Substances

  • Antihypertensive Agents