LOX out, histones: a new enzyme is nipping at your tails

Joshua C Black; Johnathan R Whetstine

doi:10.1016/j.molcel.2012.04.023

LOX out, histones: a new enzyme is nipping at your tails

Mol Cell. 2012 May 11;46(3):243-4. doi: 10.1016/j.molcel.2012.04.023.

Authors

Joshua C Black¹, Johnathan R Whetstine

Affiliation

¹ Massachusetts General Hospital Cancer Center and Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.

PMID: 22578539
DOI: 10.1016/j.molcel.2012.04.023

Abstract

In the current issue of Molecular Cell, Herranz et al. (2012) demonstrate that LOXL2 deaminates trimethylated histone 3 lysine 4 (H3K4me3), which uncovers a new chromatin modification and a new enzymatic mechanism with the potential to regulate additional lysine residues.

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