Sibling rivalry among paralogs promotes evolution of the human brain

Chris Tyler-Smith; Yali Xue

doi:10.1016/j.cell.2012.04.020

Sibling rivalry among paralogs promotes evolution of the human brain

Cell. 2012 May 11;149(4):737-9. doi: 10.1016/j.cell.2012.04.020.

Authors

Chris Tyler-Smith¹, Yali Xue

Affiliation

¹ The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK. [email protected]

Abstract

Geneticists have long sought to identify the genetic changes that made us human, but pinpointing the functionally relevant changes has been challenging. Two papers in this issue suggest that partial duplication of SRGAP2, producing an incomplete protein that antagonizes the original, contributed to human brain evolution.

Publication types

Comment
Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding