Abstract
A water-soluble derivative of N-confused porphyrin (NCP) was synthesized, and the photodynamic therapeutic (PDT) application was investigated by photophysical and in vitro studies. High singlet oxygen quantum yield in water at longer wavelength and promising IC(50) values in a panel of cancer cell lines ensure the potential candidacy of the sensitizer as a PDT drug. Reactive oxygen species (ROS) generation on PDT in MDA-MB 231 cells and the apoptotic pathway of cell death was illustrated using different techniques.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Apoptosis / drug effects
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Benzenesulfonates / chemical synthesis*
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Benzenesulfonates / chemistry
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Benzenesulfonates / pharmacology
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Cell Line, Tumor
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Chromatin / metabolism
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Drug Screening Assays, Antitumor
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Humans
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Membrane Potential, Mitochondrial / drug effects
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Methanol / chemistry
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Photochemotherapy
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Photosensitizing Agents / chemical synthesis*
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Photosensitizing Agents / chemistry
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Photosensitizing Agents / pharmacology
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Porphyrins / chemical synthesis*
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Porphyrins / chemistry
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Porphyrins / pharmacology
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Reactive Oxygen Species / metabolism
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Singlet Oxygen / chemistry
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Solubility
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Water / chemistry
Substances
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Benzenesulfonates
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Chromatin
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Photosensitizing Agents
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Porphyrins
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Reactive Oxygen Species
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meso-tetrakis(p-sulfonatophenyl)N-confused porphyrin
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Water
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Singlet Oxygen
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Methanol