Interactions between vascular endothelial growth factor and neuroglobin

Neurosci Lett. 2012 Jun 21;519(1):47-50. doi: 10.1016/j.neulet.2012.05.018. Epub 2012 May 11.

Abstract

Vascular endothelial growth factor (VEGF) and neuroglobin (Ngb) participate in neuronal responses to hypoxia and ischemia, but the relationship between their effects, if any, is unknown. To address this issue, we measured Ngb levels in VEGF-treated mouse cerebrocortical cultures and VEGF levels in cerebrocortical cultures from Ngb-overexpressing transgenic mice. VEGF stimulated Ngb expression in a VEGFR2/Flk1 receptor-dependent manner, whereas Ngb overexpression suppressed expression of VEGF. These findings provide further insight into hypoxia-stimulated neuronal signaling pathways.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cell Hypoxia / physiology
  • Cells, Cultured
  • Cerebral Cortex / metabolism*
  • Globins / metabolism*
  • Mice
  • Mice, Transgenic
  • Nerve Tissue Proteins / metabolism*
  • Neuroglobin
  • Signal Transduction / physiology*
  • Tissue Distribution
  • Vascular Endothelial Growth Factor A / metabolism*

Substances

  • Nerve Tissue Proteins
  • Neuroglobin
  • Vascular Endothelial Growth Factor A
  • vascular endothelial growth factor A, mouse
  • Globins