Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders

Am J Clin Pathol. 2012 Jun;137(6):879-89. doi: 10.1309/AJCPBPNV86VZENGV.

Abstract

We examined clinicopathologic findings in 17 cases of peripheral T-cell lymphoma, follicular variant (f-PTCL), and compared these findings with angioimmunoblastic T-cell lymphoma (AITL) to determine whether they were identical to the spectrum of changes seen in AITL and how each of the findings in f-PTCL were related to the characteristics of AITL. Almost all f-PTCL cases showed pathologic characteristics of AITL and immunohistochemical positivities in lymphoma cells for CD4, CD10, Bcl-6, PD-1, and CXCL13. Except for pathologic characteristics, clinicopathologic findings in f-PTCL had few significant differences from AITL. The positive rate for Bcl-6 expression in neoplastic cells was significantly associated with the frequency of polymorphic infiltrates, vascular proliferation, B-immunoblasts, clear cells, Epstein-Barr virus-positive lymphocytes, hepatosplenomegaly, and skin rash. Our study confirmed the continuity between f-PTCL and AITL. Moreover, Bcl-6 expression in f-PTCL was statistically associated with the characteristics of AITL.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antigens, CD / metabolism
  • Chemokine CXCL13 / metabolism
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / metabolism*
  • Disease Progression
  • Exanthema
  • Female
  • Gene Expression Regulation, Neoplastic
  • Genotype
  • Herpesvirus 4, Human / genetics
  • Humans
  • Karyotype
  • Lymphoma, Follicular / genetics
  • Lymphoma, Follicular / mortality
  • Lymphoma, Follicular / pathology*
  • Lymphoma, Large-Cell, Immunoblastic / genetics
  • Lymphoma, Large-Cell, Immunoblastic / mortality
  • Lymphoma, Large-Cell, Immunoblastic / pathology*
  • Lymphoma, T-Cell / genetics
  • Lymphoma, T-Cell / mortality
  • Lymphoma, T-Cell / pathology*
  • Lymphoma, T-Cell, Peripheral / genetics
  • Lymphoma, T-Cell, Peripheral / mortality
  • Lymphoma, T-Cell, Peripheral / pathology*
  • Male
  • Middle Aged
  • Programmed Cell Death 1 Receptor / metabolism
  • Proto-Oncogene Proteins c-bcl-6
  • Survival Analysis

Substances

  • Antigens, CD
  • BCL6 protein, human
  • Chemokine CXCL13
  • DNA-Binding Proteins
  • PDCD1 protein, human
  • Programmed Cell Death 1 Receptor
  • Proto-Oncogene Proteins c-bcl-6