New routes to old places: PIK3R1 and PIK3R2 join PIK3CA and PTEN as endometrial cancer genes

Cancer Discov. 2011 Jul;1(2):106-7. doi: 10.1158/2159-8290.CD-11-0116.

Abstract

Cheung and colleagues identify PIK3R1 and PIK3R2, the genes encoding the α and β isoforms of the phosphatidylinositol 3-kinase (PI3K) p85 regulatory subunit, as additional mutation targets in endometrial cancer, and describe a novel mechanism leading to PTEN loss.

Publication types

  • Comment

MeSH terms

  • Class Ia Phosphatidylinositol 3-Kinase / genetics*
  • Endometrial Neoplasms / genetics*
  • Female
  • Humans
  • PTEN Phosphohydrolase / genetics*
  • PTEN Phosphohydrolase / metabolism*
  • Phosphatidylinositol 3-Kinases / genetics*

Substances

  • Phosphatidylinositol 3-Kinases
  • phosphoinositol-3 kinase regulatory subunit 2, human
  • Class Ia Phosphatidylinositol 3-Kinase
  • PTEN Phosphohydrolase
  • PTEN protein, human