The potential benefits of BIM in the further pursuit of biomarker discovery in cancer therapeutics

Cancer Discov. 2011 Sep;1(4):289-90. doi: 10.1158/2159-8290.CD-11-0193.

Abstract

In this issue of Cancer Discovery, Faber and colleagues demonstrate that the basal expression of BIM is positively correlated with the amount of apoptosis induced by the corresponding tyrosine kinase inhibitor treatment within the same subtype of several oncogene-addicted cancer cell types. Their results suggest that pre-treatment assessment of BIM levels can identify patients who would benefit from molecularly targeted therapies even after biomarker-based patient selection.

Publication types

  • Comment

MeSH terms

  • Animals
  • Apoptosis Regulatory Proteins / biosynthesis*
  • Apoptosis Regulatory Proteins / genetics*
  • Bcl-2-Like Protein 11
  • Female
  • Humans
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics*
  • Membrane Proteins / biosynthesis*
  • Membrane Proteins / genetics*
  • Protein Kinase Inhibitors / pharmacology*
  • Proto-Oncogene Proteins / biosynthesis*
  • Proto-Oncogene Proteins / genetics*

Substances

  • Apoptosis Regulatory Proteins
  • BCL2L11 protein, human
  • Bcl-2-Like Protein 11
  • Membrane Proteins
  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins