Secondary resistance to erlotinib: acquired T790M mutation and small-cell lung cancer transformation in the same patient

J Thorac Oncol. 2012 Jun;7(6):1061-3. doi: 10.1097/JTO.0b013e31824fea45.
No abstract available

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Bronchoscopy
  • Cell Transformation, Neoplastic / drug effects
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / pathology
  • DNA Mutational Analysis
  • Diagnosis, Differential
  • Drug Resistance, Neoplasm / genetics*
  • ErbB Receptors / antagonists & inhibitors
  • ErbB Receptors / genetics*
  • Erlotinib Hydrochloride
  • Fatal Outcome
  • Female
  • Follow-Up Studies
  • Humans
  • Lung Neoplasms / diagnosis
  • Lung Neoplasms / drug therapy*
  • Lung Neoplasms / genetics
  • Protein Kinase Inhibitors / therapeutic use
  • Quinazolines / therapeutic use*
  • Sequence Deletion / drug effects*
  • Small Cell Lung Carcinoma / diagnosis
  • Small Cell Lung Carcinoma / drug therapy*
  • Small Cell Lung Carcinoma / genetics
  • Tomography, X-Ray Computed

Substances

  • Protein Kinase Inhibitors
  • Quinazolines
  • Erlotinib Hydrochloride
  • ErbB Receptors