Sequential use with imiquimod and surgery in extramammary Paget's disease

Dermatol Ther. 2012 Jan-Feb;25(1):82-5. doi: 10.1111/j.1529-8019.2012.01428.x.

Abstract

Extramammary Paget's disease is an uncommon intraepithelial adenocarcinoma which occurs in areas rich in apocrine glands. Although surgery is the treatment of choice, numerous noninvasive treatments have been tried. There are studies that have demonstrated the efficacy of imiquimod to treat Extramammary Paget's disease, but we found no mention in the literature of its use as neoadjuvant therapy previous to surgery excision. We present a case of a large plaque of extramammary Paget's disease successfully treated with imiquimod and minor surgery of the residual disease.

Publication types

  • Case Reports

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery
  • Aminoquinolines / administration & dosage
  • Aminoquinolines / therapeutic use*
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Combined Modality Therapy
  • Female
  • Humans
  • Imiquimod
  • Middle Aged
  • Neoadjuvant Therapy / methods
  • Paget Disease, Extramammary / drug therapy*
  • Paget Disease, Extramammary / pathology
  • Paget Disease, Extramammary / surgery
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery
  • Treatment Outcome

Substances

  • Aminoquinolines
  • Antineoplastic Agents
  • Imiquimod