Protective Effects of Nigella sativa Oil in Hyperoxia-Induced Lung Injury

Cuneyt Tayman; Ferhat Cekmez; Ilker Mustafa Kafa; Fuat Emre Canpolat; Merih Cetinkaya; Alparslan Tonbul; Sema Uysal; Turan Tunc; S Umit Sarici

doi:10.1016/j.arbres.2012.03.013

Protective Effects of Nigella sativa Oil in Hyperoxia-Induced Lung Injury

Arch Bronconeumol. 2013 Jan;49(1):15-21. doi: 10.1016/j.arbres.2012.03.013. Epub 2012 May 15.

[Article in English, Spanish]

Authors

Cuneyt Tayman¹, Ferhat Cekmez, Ilker Mustafa Kafa, Fuat Emre Canpolat, Merih Cetinkaya, Alparslan Tonbul, Sema Uysal, Turan Tunc, S Umit Sarici

Affiliation

¹ Department of Neonatology, GATA Military School of Medicine, Ankara, Turquía. [email protected]

PMID: 22592006
DOI: 10.1016/j.arbres.2012.03.013

Abstract

Background: Oxygen-induced lung injury is believed to lead to the development of bronchopulmonary dysplasia in premature infants. We have evaluated the beneficial effects of Nigella sativa oil (NSO) on rats with hyperoxia-induced lung injury.

Methods: Thirty newborn Sprague-Dawley rats were randomly divided into 3 groups as hyperoxia (95% O(2)), hyperoxia+NSO and control (21% O(2)). Pups in the hyperoxia+NSO group were administered intraperitoneal NSO at a dose of 4ml/kg daily during the study period. Histopathologic, immunochemical, and biochemical evaluations (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], malonaldehyde [MDA] and myeloperoxidase [MPO]) were performed.

Results: In the histopathologic and immunochemical evaluation, severity of lung damage was significantly lower in the hyperoxia+NOS group (P<.05). Tissue GSH-Px and SOD levels were significantly preserved, and MDA, MPO levels were significantly lower in the hyperoxia+NSO group (P<.05).

Conclusion: NSO significantly reduced the severity of lung damage due to hyperoxia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acute Lung Injury / blood
Acute Lung Injury / etiology
Acute Lung Injury / pathology
Acute Lung Injury / prevention & control*
Animals
Animals, Newborn
Disease Models, Animal
Drug Evaluation, Preclinical
Glutathione Peroxidase / analysis
Hyperoxia / complications*
Inflammation
Injections, Intraperitoneal
Lung / chemistry
Lung / pathology
Malondialdehyde / analysis
Nigella sativa / chemistry*
Oxygen Inhalation Therapy / adverse effects
Peroxidase / analysis
Phytotherapy*
Plant Oils / administration & dosage
Plant Oils / therapeutic use*
Random Allocation
Rats
Rats, Sprague-Dawley
Severity of Illness Index
Single-Blind Method
Superoxide Dismutase / analysis

Substances

Plant Oils
Malondialdehyde
caraway oil
Peroxidase
Glutathione Peroxidase
Superoxide Dismutase