Disease specific biomarkers of abdominal aortic aneurysms detected by surface enhanced laser desorption ionization time of flight mass spectrometry

Eur J Vasc Endovasc Surg. 2012 Jul;44(1):52-4. doi: 10.1016/j.ejvs.2012.04.018. Epub 2012 May 15.

Abstract

Introduction: Biomarkers have the potential to improve the clinical management of patients with AAA.

Report: A prospective, proteomics discovery study was undertaken to compare patients with AAA (n = 20) to matched screened controls (n = 19) for plasma protein expression. Surface-Enhanced-Laser-Desorption-Ionization Time of Flight Mass Spectrometry (SELDI ToF MS) coupled with Artificial Neural Networks (ANN) analysis identified six protein related diagnostic biomarker ions with a combined AUC of 0.89.

Discussion: This study discovered a signature plasma protein profile for patients with AAA and demonstrated that mass spectrometric based research for disease specific biomarker of AAA is feasible.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Aortic Aneurysm, Abdominal / blood*
  • Aortic Aneurysm, Abdominal / diagnostic imaging
  • Biomarkers / blood*
  • Disease Progression
  • Humans
  • Male
  • Prospective Studies
  • Proteomics / methods
  • Reproducibility of Results
  • Severity of Illness Index
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
  • Ultrasonography

Substances

  • Biomarkers