Abstract
Unlike in animal cells and yeasts, the Ras and Rho small G proteins and their regulators have not received extensive research attention in the case of the filamentous fungi. In an effort to begin to rectify this deficiency, the genome sequence of the basidiomycete mushroom Schizophyllum commune was searched for all known components of the Ras and Rho signalling pathways. The results of this study should provide an impetus for further detailed investigations into their role in polarized hyphal growth, sexual reproduction and fruiting body development. These processes have long been the targets for genetic and cell biological research in this fungus.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Cytoskeleton / physiology
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Fungal Proteins / genetics*
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Fungal Proteins / metabolism
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GTP-Binding Protein Regulators / genetics*
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GTP-Binding Protein Regulators / metabolism
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Gene Expression Regulation, Fungal
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Genome, Fungal*
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Humans
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Molecular Sequence Data
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Phylogeny
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Schizophyllum / genetics*
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Schizophyllum / growth & development
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Schizophyllum / metabolism
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Sequence Alignment
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Sequence Analysis, DNA
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Signal Transduction / genetics
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Signal Transduction / physiology
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ras Proteins / genetics*
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ras Proteins / metabolism
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rho GTP-Binding Proteins / genetics*
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rho GTP-Binding Proteins / metabolism
Substances
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Fungal Proteins
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GTP-Binding Protein Regulators
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ras Proteins
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rho GTP-Binding Proteins