Abstract
Antibody PG9 is a prototypical member of a class of V1/V2-directed antibodies that effectively neutralizes diverse strains of HIV-1. We analyzed strain-specific resistance to PG9 using sequence and structural information. For multiply resistant strains, mutations in a short segment of V1/V2 resulted in gain of sensitivity to PG9 and related V1/V2 neutralizing antibodies, suggesting both a common mechanism of HIV-1 resistance to and a common mode of recognition by this class of antibodies.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antibodies, Neutralizing / chemistry*
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Antibodies, Neutralizing / immunology
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HIV Antibodies / chemistry*
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HIV Antibodies / immunology
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HIV Envelope Protein gp120 / chemistry*
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HIV Envelope Protein gp120 / immunology
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HIV-1 / chemistry*
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HIV-1 / immunology
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Humans
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Structure-Activity Relationship
Substances
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Antibodies, Neutralizing
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HIV Antibodies
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HIV Envelope Protein gp120
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gp120 protein, Human immunodeficiency virus 1