Office-based slit-lamp needle revision with adjunctive mitomycin-C for late failed or encapsulated filtering blebs

Middle East Afr J Ophthalmol. 2012 Apr-Jun;19(2):216-21. doi: 10.4103/0974-9233.95255.

Abstract

Purpose: The purpose of this study was to assess the results of bleb needling in glaucomatous patients with late failed filtering blebs.

Materials and methods: A retrospective case series of 27 eyes of 27 patients was considered. All patients underwent needle bleb revision with adjuvant mitomycin-C performed at the slit lamp, during an office visit. Complete success was defined as postneedling intraocular pressure (IOP) ≤ 21 mmHg without any antiglaucoma medications and qualified success was IOP ≤ 21 mmHg with topical antiglaucoma medications.

Results: There were 12 eyes with encapsulated blebs and 15 eyes with flat blebs. The mean interval between index filtering surgery and bleb revision was 32.74 ± 15.36 months. Mean IOP was 25.07 ± 4.80 mmHg before surgery and 19.66 ± 4.97 mmHg at last postoperative follow-up. The mean follow-up was 20.31 ± 15.63 months. Complete and qualified successes were 7.4% and 51.9%, respectively. Cumulative rates of success at 1, 2, 3, and 4 years were 76%, 65%, 49%, and 37%, respectively. The mean number of antiglaucoma medications was reduced from 3.15 ± 0.36 preoperatively to 2.33 ± 1.21 postoperatively (P<0.001).

Conclusion: Slit-lamp needle revision in office is a simple and effective method for treating late encapsulated or flat filtering blebs without significant complications even for late bleb failure.

Keywords: Bleb Needling; Bleb Revision; Filtering Surgery; Glaucoma; Mitomycin-C.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Ambulatory Surgical Procedures / methods*
  • Antimetabolites, Antineoplastic / administration & dosage
  • Conjunctiva / pathology
  • Conjunctiva / surgery*
  • Female
  • Follow-Up Studies
  • Glaucoma / drug therapy
  • Glaucoma / surgery*
  • Humans
  • Intraocular Pressure
  • Male
  • Middle Aged
  • Mitomycin / administration & dosage*
  • Ostomy / instrumentation*
  • Reoperation
  • Retrospective Studies
  • Sclera / surgery*
  • Trabeculectomy
  • Treatment Failure

Substances

  • Antimetabolites, Antineoplastic
  • Mitomycin