Evasion from NK cell-mediated immune responses by HIV-1

Stephanie Jost; Marcus Altfeld

doi:10.1016/j.micinf.2012.05.001

Evasion from NK cell-mediated immune responses by HIV-1

Microbes Infect. 2012 Sep;14(11):904-15. doi: 10.1016/j.micinf.2012.05.001. Epub 2012 May 21.

Authors

Stephanie Jost¹, Marcus Altfeld

Affiliation

¹ Ragon Institute of MGH, MIT and Harvard, Bldg. 149, 13th Street, 6th Floor, Charlestown, MA 02129, USA.

Abstract

Human immunodeficiency virus type 1 (HIV-1) mostly owes its success to its ability to evade host immune responses. Understanding viral immune escape mechanisms is a prerequisite to improve future HIV-1 vaccine design. This review focuses on the strategies that HIV-1 has evolved to evade recognition by natural killer (NK) cells.

Publication types

Review

MeSH terms

HIV Infections / immunology*
HIV Infections / virology
HIV-1 / immunology*
Host-Pathogen Interactions
Humans
Immunity, Innate
Killer Cells, Natural / immunology*
Viral Vaccines / immunology*

Substances

Viral Vaccines

Grants and funding

R01 AI067031/AI/NIAID NIH HHS/United States