Emerging concepts in haematopoietic cell transplantation

Nat Rev Immunol. 2012 May 25;12(6):403-16. doi: 10.1038/nri3226.

Abstract

Haematopoietic cell transplantation (HCT) is the most widely used form of cellular therapy. It is the only known cure for some haematological malignancies and has recently been used in additional clinical settings, such as allograft tolerance induction and treatment of autoimmune diseases. Recent advances have enabled HCT in a wider range of patients with improved outcomes. This Review summarizes the latest developments in this therapy, focusing on issues that will affect future advancement.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / therapy
  • Fetal Blood / immunology
  • Graft vs Host Disease / therapy
  • HLA Antigens / immunology
  • Hematologic Neoplasms / therapy
  • Hematopoietic Stem Cell Transplantation / methods*
  • Hematopoietic Stem Cell Transplantation / standards
  • Humans
  • Transplantation Conditioning / methods

Substances

  • HLA Antigens