Gene expression of peripheral blood lymphocytes may discriminate patients with schizophrenia from controls

Mariana Maschietto; Aderbal R Silva; Renato D Puga; Leandro Lima; Carlos B Pereira; Eduardo Y Nakano; Barbara Mello; Clarissa S Gama; Paulo Belmonte-de-Abreu; Dirce M Carraro; Joana A Palha; Helena Brentani

doi:10.1016/j.psychres.2012.04.030

Gene expression of peripheral blood lymphocytes may discriminate patients with schizophrenia from controls

Psychiatry Res. 2012 Dec 30;200(2-3):1018-21. doi: 10.1016/j.psychres.2012.04.030. Epub 2012 May 26.

Authors

Mariana Maschietto¹, Aderbal R Silva, Renato D Puga, Leandro Lima, Carlos B Pereira, Eduardo Y Nakano, Barbara Mello, Clarissa S Gama, Paulo Belmonte-de-Abreu, Dirce M Carraro, Joana A Palha, Helena Brentani

Affiliation

¹ Institute of Psychiatry - University of Sao Paulo, Medical School (FMUSP), São Paulo (SP), Brazil; CIPE - AC Camargo Hospital, São Paulo (SP), Brazil.

PMID: 22633013
DOI: 10.1016/j.psychres.2012.04.030

Abstract

To identify a classifier in schizophrenia, blood gene expression profiling was applied to patients with schizophrenia under different treatments and to controls. Expression of six genes discriminated patients with sensitivity of 89.3% and specificity of 90%, supporting the use of peripheral blood as biological material for diagnosis in schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antipsychotic Agents / therapeutic use
Biomarkers / blood
Diagnosis, Differential
Female
Gene Expression Profiling
Gene Expression*
Humans
Lymphocytes / metabolism*
Male
Schizophrenia / diagnosis*
Schizophrenia / drug therapy
Schizophrenia / genetics
Schizophrenia / metabolism
Sensitivity and Specificity

Substances

Antipsychotic Agents
Biomarkers