Abstract
We investigated CD45RA and CCR7 expression in CD4+ and CD8+ subsets of cerebrospinal fluid (CSF) lymphocytes, both immediately ex vivo and after stimulation, from 134 patients with a variety of inflammatory and non-inflammatory neurological diseases. Most inflammatory diseases had a higher CD4+:CD8+ ratio and higher percentage of effector memory T cells (T(EM)) than non-inflammatory controls, excluding active infection. Moreover, we found that patients with highly elevated cell counts in the CSF tended to have a lower percentage of central memory T cells (T(CM)) than patients with low or absent pleocytosis, with a concomitant increase in T(EM). We also found that samples with elevated IgG index or presence of oligoclonal bands had a significantly higher CD4+:CD8+ ratio than normal samples, consistent with increased CD4+ help for intrathecal IgG synthesis by B cells.
Copyright © 2012 Elsevier B.V. All rights reserved.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Aged, 80 and over
-
CD4-Positive T-Lymphocytes / immunology*
-
CD4-Positive T-Lymphocytes / metabolism
-
CD8-Positive T-Lymphocytes / immunology*
-
CD8-Positive T-Lymphocytes / metabolism
-
Central Nervous System Diseases / cerebrospinal fluid*
-
Central Nervous System Diseases / immunology
-
Central Nervous System Diseases / metabolism
-
Child
-
Child, Preschool
-
Female
-
Humans
-
Immunoglobulin G / cerebrospinal fluid
-
Infant
-
Inflammation / cerebrospinal fluid
-
Inflammation / immunology
-
Inflammation / metabolism
-
Leukocyte Common Antigens / biosynthesis
-
Leukocyte Common Antigens / cerebrospinal fluid
-
Leukocyte Common Antigens / immunology
-
Male
-
Middle Aged
-
Receptors, CCR7 / analysis
-
Receptors, CCR7 / biosynthesis
-
Receptors, CCR7 / immunology
-
T-Lymphocyte Subsets / immunology*
-
T-Lymphocyte Subsets / metabolism
-
Young Adult
Substances
-
CCR7 protein, human
-
Immunoglobulin G
-
Receptors, CCR7
-
Leukocyte Common Antigens