Involvement of a putative cyclic amp receptor protein (CRP)-like binding sequence and a CRP-like protein in glucose-mediated catabolite repression of thn genes in Rhodococcus sp. strain TFB

Appl Environ Microbiol. 2012 Aug;78(15):5460-2. doi: 10.1128/AEM.00700-12. Epub 2012 May 25.

Abstract

Glucose catabolite repression of tetralin catabolic genes in Rhodococcus sp. strain TFB was shown to be exerted by a protein homologous to transcriptional regulators of the cyclic AMP receptor (CRP)-FNR family. The protein was detected bound to putative CRP-like boxes localized at the promoters of the thnA1 and thnS genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism*
  • Catabolite Repression / genetics
  • Catabolite Repression / physiology*
  • Cyclic AMP Receptor Protein / metabolism*
  • Electrophoresis, Polyacrylamide Gel
  • Electroporation
  • Glucose / metabolism*
  • Green Fluorescent Proteins
  • Mutagenesis
  • Plasmids / genetics
  • Polymerase Chain Reaction
  • Promoter Regions, Genetic / genetics
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rhodococcus / metabolism
  • Rhodococcus / physiology*
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Tetrahydronaphthalenes / metabolism*

Substances

  • Bacterial Proteins
  • Cyclic AMP Receptor Protein
  • Tetrahydronaphthalenes
  • Green Fluorescent Proteins
  • tetralin
  • Glucose