Cervical cancer

Obstet Gynecol Clin North Am. 2012 Jun;39(2):233-53. doi: 10.1016/j.ogc.2012.02.008. Epub 2012 Apr 24.

Abstract

Squamous cell cervical cancer incidence and mortality have been reduced dramatically as a result of successful screening in many countries. The incidence of cervical adenocarcinoma continues to increase. There has been concentrated effort toward improving early detection and screening by utilizing molecular biomarker assays. The FIGO staging system for cervical cancer was revised in 2009. Fertility preservation can be offered to patients with early-stage cervical cancer through radical trachelectomy, although radical hysterectomy remains the surgical standard of care. Concurrent chemotherapy with radiation has been shown to have a survival advantage in patients with advanced-stage disease. Improvements in radiation techniques and molecular targeted therapy are the current research venues in cervical cancer.

MeSH terms

  • Adult
  • Carcinoma, Squamous Cell / epidemiology
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / therapy
  • Female
  • Humans
  • Hysterectomy* / methods
  • Incidence
  • Mass Screening
  • Middle Aged
  • Neoplasm Staging
  • Papillomavirus Infections / complications*
  • Papillomavirus Infections / virology
  • Papillomavirus Vaccines / administration & dosage
  • Risk Factors
  • Smoking / adverse effects
  • Socioeconomic Factors
  • United States / epidemiology
  • Uterine Cervical Neoplasms* / epidemiology
  • Uterine Cervical Neoplasms* / pathology
  • Uterine Cervical Neoplasms* / surgery
  • Uterine Cervical Neoplasms* / therapy
  • Uterine Cervical Neoplasms* / virology
  • Vaginal Smears

Substances

  • Papillomavirus Vaccines