Abstract
Cells derived from cell-cell fusion events were clonally isolated from primary methylcholanthrene (MCA)-induced tumors in allophenic mice. Compared with non-fused cells isolated from the same cultures, the fused cells had markedly greater experimental metastasizing (lung colonizing) activity, but only slightly greater tumorigenicity and the same cloning efficiency in soft agar. Cell-cell fusion may thus contribute to the generation of tumor heterogeneity that underlies the process of tumor progression.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cell Fusion / physiology
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Clone Cells / cytology
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Glucose-6-Phosphate Isomerase / genetics
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Glucose-6-Phosphate Isomerase / metabolism
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Lung Neoplasms / genetics
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Lung Neoplasms / secondary*
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Methylcholanthrene
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Mice
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Mice, Inbred Strains
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Neoplasm Metastasis / genetics*
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Neoplasm Transplantation
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Neoplasms, Experimental / chemically induced
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Neoplasms, Experimental / enzymology
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Neoplasms, Experimental / genetics
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Neoplasms, Experimental / pathology*
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Tumor Cells, Cultured
Substances
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Methylcholanthrene
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Glucose-6-Phosphate Isomerase