Genetic variability in swine leukocyte antigen class II and Toll-like receptors affects immune responses to vaccination for bacterial infections in pigs

H Shinkai; A Arakawa; M Tanaka-Matsuda; H Ide-Okumura; K Terada; M Chikyu; T Kawarasaki; A Ando; H Uenishi

doi:10.1016/j.cimid.2012.05.003

Genetic variability in swine leukocyte antigen class II and Toll-like receptors affects immune responses to vaccination for bacterial infections in pigs

Comp Immunol Microbiol Infect Dis. 2012 Dec;35(6):523-32. doi: 10.1016/j.cimid.2012.05.003. Epub 2012 Jun 1.

Authors

H Shinkai¹, A Arakawa, M Tanaka-Matsuda, H Ide-Okumura, K Terada, M Chikyu, T Kawarasaki, A Ando, H Uenishi

Affiliation

¹ Division of Animal Sciences, National Institute of Agrobiological Sciences, 2 Ikenodai, Tsukuba, Ibaraki 305-8602, Japan.

PMID: 22658914
DOI: 10.1016/j.cimid.2012.05.003

Abstract

The genes encoding swine leukocyte antigen (SLA) and Toll-like receptor (TLR) are highly polymorphic in pig populations, and likely have influences on infection and the effects of vaccination. We explored the associations of different genotypes of SLA class II and of the genes TLR1, TLR4, TLR5, and TLR6 with antibody responses after vaccination against Erysipelothrix rhusiopathiae (ER) and Actinobacillus pleuropneumoniae (APP) serotypes 1, 2, and 5 in 191 Duroc pigs maintained under specific pathogen-free conditions. We demonstrated close relationships between SLA class II and ER antibody response and between TLR genes other than TLR4 and APP antibody responses. Pigs with specific haplotypes in SLA class II or TLR5 showed decreased antibody response to ER vaccination or increased responses to APP2 and APP5 vaccination, respectively. It might be possible to breed for responsiveness to vaccination and to implement new vaccine development strategies unaffected by genetic backgrounds of pigs.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actinobacillus Infections / immunology
Actinobacillus Infections / prevention & control
Actinobacillus Infections / veterinary*
Actinobacillus pleuropneumoniae / immunology
Animals
Antibodies, Bacterial / biosynthesis
Antibodies, Bacterial / immunology
Bacterial Vaccines / immunology*
Chromosome Mapping
Erysipelothrix / immunology
Erysipelothrix Infections / immunology
Erysipelothrix Infections / prevention & control*
Female
Genetic Variation
Genotyping Techniques
Histocompatibility Antigens Class II / genetics
Histocompatibility Antigens Class II / immunology
Male
Swine
Swine Diseases / immunology
Swine Diseases / prevention & control*
Toll-Like Receptor 1 / genetics
Toll-Like Receptor 1 / immunology
Toll-Like Receptor 4 / genetics
Toll-Like Receptor 4 / immunology
Toll-Like Receptor 5 / genetics
Toll-Like Receptor 5 / immunology
Toll-Like Receptor 6 / genetics
Toll-Like Receptor 6 / immunology
Vaccination*
Vaccines, Inactivated

Substances

Antibodies, Bacterial
Bacterial Vaccines
Histocompatibility Antigens Class II
Toll-Like Receptor 1
Toll-Like Receptor 4
Toll-Like Receptor 5
Toll-Like Receptor 6
Vaccines, Inactivated