This study aimed to develop and evaluate the virtual classroom on the Theory of Meaningful learning for undergraduates in nursing. It is applied research, production technology, developed in five phases: design and planning, content development and instructional designer, creation of educational materials, learning portal deployment in Moodle (Modular Object-Oriented Dynamic Learning Environment) and evaluation by judges. The class was developed and was approved, after evaluation by the judges, and adjustments, and will integrate the discipline Methodology of Nursing Teaching I, Degree Course Nursing School of USP. We believe that the purpose of this study favors the formation of the licensing and therefore the future of teaching nursing in a critical and reflective, with the components of a profile of the prospect of seeking and using new knowledge for the development of their professional practice.