Context: Giant cell tumor of soft tissue is a rare primary soft tissue tumor with low malignant potential. It is clinically and pathologically similar to the giant cell tumor of the bone.
Case report: We report a case of a 28-year-old man complaining of a painless solitary nodule arising in the spinal muscle of the neck. Computed tomography suggested a neurogenic tumor, but the diagnosis of giant cell tumor was confirmed after detailed pathological examination. The patient remains disease free five months after diagnosis.
Conclusion: It is important to recognize this pathological entity in order to avoid misdiagnosis with other fibrous tumors associated with giant cells.
Keywords: Giant cell tumor; histopathology; soft tissue neck.