Abstract
Tumor-associated macrophages (TAMs) might be associated with worse outcome in classical Hodgkin lymphoma (cHL). Our aim was to determine whether TAMs correlated with refractoriness in cHL. In a cohort of 18 consecutive primary refractory or early relapsed cases and 41 randomly selected controls (responder patients), high TAM infiltration was significantly associated with refractoriness or early relapse (p = 0.004) and remained independently correlated with outcome in multivariate analysis (odds ratio 8.276, 95% confidence interval 1.214-56.408). This study provides evidence that the marker CD68 might accurately predict early outcome of de novo cHL and could be used in combination with c-kit and TiA1 staining.
MeSH terms
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Adult
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Aged
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Antigens, CD / metabolism*
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Antigens, Differentiation, Myelomonocytic / metabolism*
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Biomarkers, Tumor
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Female
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Hodgkin Disease / immunology*
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Hodgkin Disease / metabolism*
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Hodgkin Disease / mortality
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Humans
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Macrophages / immunology
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Macrophages / metabolism*
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Male
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Mast Cells / immunology
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Mast Cells / metabolism*
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Middle Aged
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Neoplasm Staging
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Poly(A)-Binding Proteins / metabolism
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Prognosis
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Proto-Oncogene Proteins c-kit / metabolism
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Recurrence
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T-Cell Intracellular Antigen-1
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T-Lymphocytes / immunology
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T-Lymphocytes / metabolism*
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Tumor Microenvironment / immunology
Substances
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Antigens, CD
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Antigens, Differentiation, Myelomonocytic
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Biomarkers, Tumor
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CD68 antigen, human
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Poly(A)-Binding Proteins
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T-Cell Intracellular Antigen-1
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TIA1 protein, human
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Proto-Oncogene Proteins c-kit