Posttransplant lymphoproliferative disorder presenting as a nonhealing extraction socket: a case report and review of the literature

Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 May;113(5):e12-8. doi: 10.1016/j.oooo.2011.10.015. Epub 2012 Mar 3.

Abstract

Posttransplant lymphoproliferative disorder (PTLD) is a well-recognized complication of long-term immunosuppression following hematopoietic or solid organ transplantation and is associated with significant morbidity and mortality. We present a unique case of PTLD that manifested with a nonhealing dental extraction socket 17 years after renal transplantation. We summarize the existing literature and present a review of an additional 25 cases. These highlight the variable clinical presentations of PTLD within the oral cavity and clear potential for delayed presentation at this anatomical subsite.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Administration, Oral
  • Alendronate / administration & dosage
  • Antibodies, Monoclonal, Murine-Derived / therapeutic use
  • Antineoplastic Agents / therapeutic use
  • Bisphosphonate-Associated Osteonecrosis of the Jaw / diagnosis
  • Bone Density Conservation Agents / administration & dosage
  • Diagnosis, Differential
  • Humans
  • Immunosuppression Therapy / adverse effects
  • Kidney Transplantation / adverse effects*
  • Lymphoproliferative Disorders / etiology*
  • Lymphoproliferative Disorders / pathology
  • Lymphoproliferative Disorders / therapy
  • Male
  • Mandibular Neoplasms / drug therapy
  • Mandibular Neoplasms / radiotherapy
  • Middle Aged
  • Molar / surgery
  • Rituximab
  • Tooth Extraction / adverse effects*
  • Tooth Socket / pathology*

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Agents
  • Bone Density Conservation Agents
  • Rituximab
  • Alendronate