Parallel relaxation of stringent RNA recognition in plant and mammalian L1 retrotransposons

Mol Biol Evol. 2012 Nov;29(11):3255-9. doi: 10.1093/molbev/mss147. Epub 2012 Jun 5.

Abstract

L1 elements are mammalian non-long terminal repeat retrotransposons, or long interspersed elements (LINEs), that significantly influence the dynamics and fluidity of the genome. A series of observations suggest that plant L1-clade LINEs, just as mammalian L1s, mobilize both short interspersed elements (SINEs) and certain messenger RNA by recognizing the 3'-poly(A) tail of RNA. However, one L1 lineage in monocots was shown to possess a conserved 3'-end sequence with a solid RNA structure also observed in maize and sorghum SINEs. This strongly suggests that plant LINEs require a particular 3'-end sequence during initiation of reverse transcription. As one L1-clade LINE was also found to share the 3'-end sequence with a SINE in a green algal genome, I propose that the ancestral L1-clade LINE in the common ancestor of green plants may have recognized the specific RNA template, with stringent recognition then becoming relaxed during the course of plant evolution.

Publication types

  • Letter

MeSH terms

  • Animals
  • Long Interspersed Nucleotide Elements / genetics*
  • Mammals / genetics*
  • Models, Genetic
  • Phylogeny
  • Plants / genetics*
  • RNA / genetics*

Substances

  • RNA