Methylsulfonyl benzothiazole (MSBT): a selective protein thiol blocking reagent

Org Lett. 2012 Jul 6;14(13):3396-9. doi: 10.1021/ol301370s. Epub 2012 Jun 8.

Abstract

A new thiol blocking reagent, methylsulfonyl benzothiazole, was discovered. This reagent showed good selectivity and high reactivity for protein thiols.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzothiazoles / chemistry*
  • Hydrogen-Ion Concentration
  • Molecular Structure
  • Proteins / chemistry*
  • Sulfhydryl Compounds / chemistry*

Substances

  • Benzothiazoles
  • Proteins
  • Sulfhydryl Compounds
  • methylsulfonyl benzothiazole