Insulin-like growth factors in normal and diseased kidney

Endocrinol Metab Clin North Am. 2012 Jun;41(2):351-74, vii. doi: 10.1016/j.ecl.2012.04.015.

Abstract

This article reviews the physiology of the insulin-like growth factor (IGF) system in the kidney and the changes and potential role of this system in selected renal diseases. The potential therapeutic uses of recombinant human IGF-I for the treatment of acute and chronic kidney failure are briefly discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Insulin-Like Growth Factor Binding Proteins / physiology
  • Kidney / metabolism
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / metabolism*
  • Mice
  • Rats
  • Somatomedins / physiology*
  • Somatomedins / therapeutic use*

Substances

  • Insulin-Like Growth Factor Binding Proteins
  • Somatomedins