New crystal structure of the proteasome-dedicated chaperone Rpn14 at 1.6 Å resolution

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 May 1;68(Pt 5):517-21. doi: 10.1107/S1744309112011359. Epub 2012 Apr 20.

Abstract

The 26S proteasome is an ATP-dependent protease responsible for selective degradation of polyubiquitylated proteins. Recent studies have suggested that proteasome assembly is a highly ordered multi-step process assisted by specific chaperones. Rpn14, an assembly chaperone for ATPase-ring formation, specifically recognizes the ATPase subunit Rpt6. The structure of Rpn14 at 2.0 Å resolution in space group P6(4) has previously been reported, but the detailed mechanism of Rpn14 function remains unclear. Here, a new crystal structure of Rpn14 with an E384A mutation is presented in space group P2(1) at 1.6 Å resolution. This high-resolution structure provides a framework for understanding proteasome assembly.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Carrier Proteins / chemistry*
  • Carrier Proteins / genetics
  • Hydrogen Bonding
  • Models, Molecular
  • Molecular Sequence Data
  • Mutation
  • Proteasome Endopeptidase Complex
  • Protein Structure, Quaternary
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae / chemistry*
  • Saccharomyces cerevisiae Proteins / chemistry*
  • Saccharomyces cerevisiae Proteins / genetics
  • Structural Homology, Protein

Substances

  • Carrier Proteins
  • Saccharomyces cerevisiae Proteins
  • Proteasome Endopeptidase Complex
  • Rpn14 protein, S cerevisiae