Prevalence of transmitted antiretroviral drug resistance differs between acutely and chronically HIV-infected patients

J Acquir Immune Defic Syndr. 2012 Oct 1;61(2):258-62. doi: 10.1097/QAI.0b013e3182618f05.

Abstract

The associations of acute HIV infection (AHI) and other predictors with transmitted drug resistance (TDR) prevalence were assessed in a cohort of HIV-infected, antiretroviral-naïve patients. AHI was defined as being seronegative with detectable HIV RNA. Binomial regression was used to estimate prevalence ratios and 95% confidence intervals for associations with TDR. Among 43 AHI patients, TDR prevalence was 20.9%, whereas prevalence was 8.6% among 677 chronically infected patients. AHI was associated with 1.9 times the prevalence of TDR (95% confidence intervals: 1.0 to 3.6) in multivariable analysis. AHI patients may represent a vanguard group that portends increasing TDR in the future.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Adult
  • Anti-Retroviral Agents / administration & dosage
  • Anti-Retroviral Agents / pharmacology*
  • Chronic Disease
  • Cohort Studies
  • Drug Resistance, Viral*
  • Female
  • HIV / drug effects*
  • HIV Infections / transmission*
  • HIV Infections / virology*
  • Humans
  • Male
  • Middle Aged
  • Prevalence
  • RNA, Viral / blood

Substances

  • Anti-Retroviral Agents
  • RNA, Viral