Tracing back the nascence of a new sex-determination pathway to the ancestor of bees and ants

Nat Commun. 2012 Jun 12:3:895. doi: 10.1038/ncomms1898.

Abstract

In several Hymenoptera, sexual fate is determined by the allelic composition at the complementary sex-determiner locus, a sex-determination mechanism that can strongly affect population dynamics. To date, the molecular identification of complementary sex determiner has only been achieved in the honeybee, where the complementary sex-determiner gene was reported to have arisen from duplication of the feminizer gene. Strikingly, the complementary sex-determiner gene was also proposed to be unique to the honeybee lineage. Here we identify feminizer and complementary sex-determiner orthologues in bumble bees and ants. We further demonstrate that the duplication of feminizer that produced complementary sex determiner occurred before the divergence of Aculeata species (~120 Myr ago). Finally, we provide evidence that the two genes evolved concertedly through gene conversion, complementary sex-determiner evolution being additionally shaped by mosaic patterns of selection. Thus, the complementary sex-determiner gene likely represents the molecular basis for single locus-complementary sex determination in the Aculeata infra-order, and possibly, in the entire Hymenoptera order.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Ants / genetics
  • Ants / growth & development*
  • Ants / metabolism
  • Bees / genetics
  • Bees / growth & development*
  • Bees / metabolism
  • Evolution, Molecular
  • Female
  • Insect Proteins / genetics
  • Insect Proteins / metabolism
  • Male
  • Sex Determination Processes / genetics
  • Sex Determination Processes / physiology*

Substances

  • Insect Proteins