A monoreactive bifunctional triazacyclononane phosphinate chelator with high selectivity for gallium-68

ChemMedChem. 2012 Aug;7(8):1375-8. doi: 10.1002/cmdc.201200261. Epub 2012 Jun 12.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Aza Compounds / chemical synthesis
  • Aza Compounds / chemistry*
  • Cell Line, Tumor
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry*
  • Gallium Radioisotopes / chemistry
  • Humans
  • Integrin alphaVbeta3 / metabolism
  • Melanoma / diagnostic imaging
  • Mice
  • Mice, Nude
  • Pancreatic Neoplasms / diagnostic imaging
  • Peptides / chemistry
  • Phosphinic Acids / chemical synthesis
  • Phosphinic Acids / chemistry*
  • Piperidines / chemistry*
  • Positron-Emission Tomography
  • Radiopharmaceuticals / chemical synthesis
  • Radiopharmaceuticals / chemistry*
  • Rats
  • Transplantation, Heterologous

Substances

  • 1,4,7-triazacyclononane-1-(methyl(2-carboxyethyl)phosphinic acid)-4,7-bis(methyl(2-hydroxymethyl)phosphinic acid)
  • Aza Compounds
  • Chelating Agents
  • Gallium Radioisotopes
  • Integrin alphaVbeta3
  • Peptides
  • Phosphinic Acids
  • Piperidines
  • Radiopharmaceuticals
  • triazacyclononane