Rolling the dice to discover the role of DICER in tumorigenesis

Veronica Davalos; Manel Esteller

doi:10.1016/j.ccr.2012.05.030

Rolling the dice to discover the role of DICER in tumorigenesis

Cancer Cell. 2012 Jun 12;21(6):717-9. doi: 10.1016/j.ccr.2012.05.030.

Authors

Veronica Davalos¹, Manel Esteller

Affiliation

¹ Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, 08908 Catalonia, Spain.

PMID: 22698397
DOI: 10.1016/j.ccr.2012.05.030

Abstract

In an effort to identify the consequences of complete DICER1 loss in tumorigenesis, in this issue of Cancer Cell, Ravi et al. characterize the effects of homozygous deletion of Dicer1. Using an in vivo mouse model, they show that genetic deletion of Dicer1 does not preclude tumor formation.

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