Refractory Salmonella enterica serotype choleraesuis-related renal cyst infection in a patient with autosomal dominant polycystic kidney disease undergoing hemodialysis treated successfully with intracystic ciprofloxacin infusion

Med Princ Pract. 2012;21(6):576-8. doi: 10.1159/000339199. Epub 2012 Jun 15.

Abstract

Objective: To report a potential salvage therapy for refractory renal cyst infection secondary to Salmonellaenterica serotype choleraesuis (S. choleraesuis).

Clinical presentation and intervention: A 52-year-old male with autosomal dominant polycystic kidney disease undergoing hemodialysis experienced an episode of S. choleraesuis-related gastroenteritis subsequently complicated by bloodstream and refractory renal cyst infection with formation of multiple pyocysts. The patient was treated with intracystic indwelling diluted ciprofloxacin solution.

Conclusion: In this patient, intracystic infusion of ciprofloxacin achieved a sufficient antibiotic level in infected renal cysts and hence completely eradicated S. choleraesuis. Therefore, intracystic antiobiotic infusion could be a potential salvage therapy for refractory renal cyst infection.

Publication types

  • Case Reports

MeSH terms

  • Anti-Infective Agents / therapeutic use*
  • Ciprofloxacin / administration & dosage
  • Ciprofloxacin / therapeutic use*
  • Cysts / diagnosis
  • Cysts / drug therapy*
  • Cysts / microbiology
  • Gastroenteritis / complications
  • Humans
  • Male
  • Middle Aged
  • Polycystic Kidney, Autosomal Dominant / complications*
  • Polycystic Kidney, Autosomal Dominant / therapy
  • Renal Dialysis
  • Salmonella Infections / diagnosis
  • Salmonella Infections / drug therapy*
  • Salmonella Infections / etiology
  • Salmonella enterica / isolation & purification*
  • Treatment Outcome

Substances

  • Anti-Infective Agents
  • Ciprofloxacin