Cucurbit[7]uril pseudorotaxane-based photoresponsive supramolecular nanovalve

Yu-Long Sun; Bing-Jie Yang; Sean Xiao-An Zhang; Ying-Wei Yang

doi:10.1002/chem.201201083

Cucurbit[7]uril pseudorotaxane-based photoresponsive supramolecular nanovalve

Chemistry. 2012 Jul 23;18(30):9212-6. doi: 10.1002/chem.201201083. Epub 2012 Jun 20.

Authors

Yu-Long Sun¹, Bing-Jie Yang, Sean Xiao-An Zhang, Ying-Wei Yang

Affiliation

¹ State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, 2699 Qianjin Street, Changchun, Jilin 130012, PR China.

PMID: 22718563
DOI: 10.1002/chem.201201083

Abstract

Light relief! Mesoporous silica materials equipped with photoresponsive cucurbit[7]uril-pseudorotaxane nanovalves operate in biological media to trap cargo molecules within nanopores, but undergo controlled release when irradiated with light of a suitable wavelength (see figure). Significantly, a "ladder"-release pattern is obtained to balance maximal therapeutic efficacy and minimal dose frequency in the development of "pulsed" drug therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bridged-Ring Compounds / chemistry*
Hydrogen-Ion Concentration
Imidazoles / chemistry*
Magnetic Resonance Spectroscopy
Molecular Structure
Nanoparticles / chemistry*
Nanopores
Photolysis
Rotaxanes / chemistry*
Silicon Dioxide / chemistry*

Substances

Bridged-Ring Compounds
Imidazoles
Rotaxanes
cucurbit(7)uril
Silicon Dioxide