Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity

J G Ondeyka; R T Goegelman; J M Schaeffer; L Kelemen; L Zitano

doi:10.7164/antibiotics.43.1375

Novel antinematodal and antiparasitic agents from Penicillium charlesii. I. Fermentation, isolation and biological activity

J Antibiot (Tokyo). 1990 Nov;43(11):1375-9. doi: 10.7164/antibiotics.43.1375.

Authors

J G Ondeyka¹, R T Goegelman, J M Schaeffer, L Kelemen, L Zitano

Affiliation

¹ Merck & Co., Inc., Rahway, New Jersey 07065-0900.

PMID: 2272914
DOI: 10.7164/antibiotics.43.1375

Abstract

Paraherquamide and six novel analogs were isolated from the fermentation of Penicillium charlesii (ATCC 20841). All seven natural products displayed potent antinematodal activity against Caenorhabditis elegans. None of the novel analogs were more potent than paraherquamide.

MeSH terms

Animals
Anthelmintics / isolation & purification*
Anthelmintics / pharmacology
Antinematodal Agents / isolation & purification*
Antinematodal Agents / pharmacology
Caenorhabditis / drug effects*
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Culture Media
Fermentation
Indolizines / isolation & purification*
Indolizines / pharmacology
Penicillium / metabolism*
Soil Microbiology
Spiro Compounds / isolation & purification*
Spiro Compounds / pharmacology

Substances

Anthelmintics
Antinematodal Agents
Culture Media
Indolizines
Spiro Compounds
paraherquamide