Antimycobacterial activity of pyrimido[4,5-b]diazepine derivatives

Arch Pharm (Weinheim). 2012 Sep;345(9):739-44. doi: 10.1002/ardp.201100433. Epub 2012 Jun 25.

Abstract

Three series of novel 8,9-dihydro-7H-pyrimido[5,4-b][1,4]diazepines, 4a-d, 5a-d, and 7a-d, were efficiently obtained in good yields using simple reaction methodologies. These pyrimidodiazepines were evaluated against 15 Mycobacterium spp. strains. Moderate activity in the inhibition of 13 microorganisms was obtained for the four compounds 4a, 5a, 5c, and 5d.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Azepines / chemical synthesis*
  • Azepines / chemistry
  • Azepines / pharmacology
  • Drug Design*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium / drug effects
  • Mycobacterium / growth & development
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry
  • Pyrimidines / pharmacology

Substances

  • Anti-Bacterial Agents
  • Azepines
  • Pyrimidines