Introduction: Cognitive impairment is common in Parkinson's disease (PD), even in the early stages, and appropriate screening tools are needed.
Methods: We investigated the utility of the Addenbrooke's Cognitive Examination-Revised for detecting mild cognitive impairment (MCI) in PD in an incident population-representative cohort (n = 132) and investigated the relationship between performance on this instrument and behavior and quality of life (n = 219).
Results: Twenty-two percent met criteria for MCI. Receiver operating curve analysis revealed an area under the curve of 0.81. A cutoff <89 gave a sensitivity of 69% and specificity of 84%. Scores on this instrument were highly correlated with the Parkinson's Disease Cognitive Rating Scale, and there were significant correlations with the Cambridge Behavioral Inventory-Revised and Parkinson's Disease Questionnaire 39.
Conclusion: This instrument is a useful screening tool for PD-MCI, and poor performance is significantly related to impaired behavior and quality of life.
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