[Network-based local and global consistency of cardiovascular genes]

Xiaohan Zuo; Peng Lu; Xi Liu; Jianxin Chen; Yibo Gao; Yiping Yang; Hongjun Yang

[Network-based local and global consistency of cardiovascular genes]

Zhongguo Zhong Yao Za Zhi. 2012 Jan;37(2):130-3.

[Article in Chinese]

Authors

Xiaohan Zuo¹, Peng Lu, Xi Liu, Jianxin Chen, Yibo Gao, Yiping Yang, Hongjun Yang

Affiliation

¹ Institute of Automation Chinese Academy of Sciences, Beijing 100190, China.

PMID: 22737837

Abstract

Drug targets discovery is one of the most important elements in new drug development, and a variety of methods have been developed recently from this point of view. This paper proposed a network-based local and global consistency for cardiovascular genes identification. Results were evaluated through the widely used database HPRD and DrugBank. Results showed that our algorithm can give reasonable candidate targets set. The method in this paper could be an impressive solution for targets searching.

Publication types

English Abstract

MeSH terms

Algorithms*
Cardiovascular Diseases / genetics
Cardiovascular Diseases / metabolism*
Cardiovascular Diseases / prevention & control
Databases, Protein
Drug Delivery Systems / methods
Drug Discovery / methods
Gene Regulatory Networks
Humans
Models, Theoretical
Pharmaceutical Preparations / administration & dosage
Pharmaceutical Preparations / metabolism*
Protein Binding
Protein Interaction Mapping / methods*
Proteins / genetics
Proteins / metabolism*

Substances

Pharmaceutical Preparations
Proteins