Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents

Sandip N Gavade; Vijay L Markad; Kisan M Kodam; Murlidhar S Shingare; Dhananjay V Mane

doi:10.1016/j.bmcl.2012.05.111

Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5075-7. doi: 10.1016/j.bmcl.2012.05.111. Epub 2012 Jun 9.

Authors

Sandip N Gavade¹, Vijay L Markad, Kisan M Kodam, Murlidhar S Shingare, Dhananjay V Mane

Affiliation

¹ PG Department of Chemistry and Research Center, SCS College, Omerga, India.

PMID: 22742908
DOI: 10.1016/j.bmcl.2012.05.111

Abstract

A series of 2,4,6-trisubstituted [1,3,5]triazines were synthesized and evaluated for their antimicrobial activity against two representative Gram-positive, Gram-negative bacteria and two fungi. Biological data revealed that among all the compounds screened, compounds 3f, 3g, 3h, 3i, 3m, 3o and 3p found to have promising antimicrobial activity against all the selected pathogenic bacteria and fungi. Out of the synthesized compounds seven analogues have shown MIC in the range of 6.25-12.5 μg/mL. These compounds were generally nontoxic and may prove useful as antimicrobial agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemical synthesis*
Anti-Infective Agents / chemistry
Anti-Infective Agents / pharmacology
Fungi / drug effects
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Structure-Activity Relationship
Triazines / chemical synthesis
Triazines / chemistry*
Triazines / pharmacology

Substances

Anti-Infective Agents
Triazines