Bone mineral crystallisation kinetics

J Mater Sci Mater Med. 2012 Sep;23(9):2055-60. doi: 10.1007/s10856-012-4679-2. Epub 2012 Jun 29.

Abstract

The kinetics of bone apatite crystallisation are examined using a novel approach to obtain quantitative, direction dependence features such as growth rate and activation energy. X-ray diffraction was employed for analysis of bovine, porcine and 'anorganic' bone specimens. Apatite coherence length was utilised as the independent variable within a Johnson-Mehl-Avrami (JMA) model. A direction averaged crystallisation activation energy of 183 ± 8 kJ mol(-1) was observed for the three bone groups. The Johnson-Mehl-Avrami 'n' exponent decreased with increasing temperature for all bone groups, indicating that apatite crystallisation changes to a diffusion limited process at higher temperatures. The results revealed little evidence to support any organic component 'protective' effect, and, on the contrary indicated that the organic matrix promotes apatite crystallisation.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Apatites / chemistry
  • Apatites / pharmacokinetics
  • Bone Substitutes / chemical synthesis*
  • Bone Substitutes / chemistry
  • Bone Substitutes / pharmacokinetics
  • Bone and Bones / chemistry*
  • Bone and Bones / metabolism
  • Calcification, Physiologic / physiology*
  • Calorimetry, Differential Scanning
  • Cattle
  • Cementation / methods
  • Crystallization
  • Kinetics
  • Swine
  • Temperature
  • Time Factors
  • X-Ray Diffraction

Substances

  • Apatites
  • Bone Substitutes