Symmetrical drug-related intertriginous and flexural exanthema secondary to topical 5-fluorouracil

Roxann Powers; Rachel Gordon; Kenrick Roberts; Rodney Kovach

Symmetrical drug-related intertriginous and flexural exanthema secondary to topical 5-fluorouracil

Cutis. 2012 May;89(5):225-8.

Authors

Roxann Powers¹, Rachel Gordon, Kenrick Roberts, Rodney Kovach

Affiliation

¹ West Virginia University School of Medicine, Morgantown, WV 26506, USA. [email protected]

PMID: 22768435

Abstract

We report the case of a 56-year-old man who developed a distinctive skin eruption after treating actinic keratoses on the dorsal aspects of his right and left hands with topical 5-fluorouracil (5-FU). The distribution of his rash was characteristic of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), also known as baboon syndrome.

Publication types

Case Reports

MeSH terms

Administration, Cutaneous
Drug Eruptions / etiology*
Drug Eruptions / pathology
Exanthema / chemically induced*
Exanthema / pathology
Fluorouracil / administration & dosage
Fluorouracil / adverse effects*
Fluorouracil / therapeutic use
Hand Dermatoses / chemically induced
Hand Dermatoses / pathology
Humans
Immunosuppressive Agents / administration & dosage
Immunosuppressive Agents / adverse effects*
Keratosis, Actinic / drug therapy
Male
Middle Aged

Substances

Immunosuppressive Agents
Fluorouracil